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The FDR for associated SNPs for any cycle FN was 0.47 and 0.33 for cycle 1 FN.
Among the 11 NHL patients receiving dose-dense chemotherapy, 3 patients (27%) received PP and 7 (64%) received SP. The rate of FN occurring in protected cycles was 10% (1 FN in a patient receiving PP), while the FN rate in unprotected cycles was 75% (6 FN in the 8 patients with at least 1 unprotected cycle).
While a higher PPV is desirable, it should be remembered that the PPV in this setting was partially driven by a low absolute frequency of cycle 1 FN events and that not every patient who is at high risk of FN will actually experience FN.
Whilst the presence of some risk factors alone (e.g. low baseline albumin) did not predict a high risk of FN, a combination of risk factors increased the predicted risk for developing cycle 1 FN substantially.
In summary, this study describes a prospective multivariate risk model that was able to identify clinically relevant factors that were predictive or protective of cycle 1 FN and correctly identify a high proportion of patients at risk of first cycle FN.
This indicates that the nonlinear vibration of a graphene resonator can be easily observed even when the actuation amplitude is applied in the order of 1 fN.
Similar(22)
We then calculated the Sp statistic, defined as Sp = −b(Ld10)/(1− FN), where FN is the mean Fij between neighboring individuals, which was approximated by F d) for the first distance interval (Vekemans and Hardy 2004; Hardy et al. 2006).
In addition to collagen genes, we also determined the expression of fibronectin 1 (FN-1) and matrix metalloproteinase-14 (MMP-14) in WT and M 2 mutant minus-lens-induced myopic sclera with and without muscarinic antagonists.
1- FN: Participated in design of method, design of study and collecting of samples and drafted the manuscript.
Among patients with fever episodes, two (5.0%) in the biosimilar and none in the reference arm had ≥1 FN episode.
In addition, we observed that treatment with Gal-1, FN, and/or LM-5 stimulated motility and then increased FAK, Akt, and Erk phosphorylation/expression.
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