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By applying the default SPThres values (Table 1), ESC ensures high F-score performance, with precision/recall balance.
(NPG-3, NPG-4, NPG-5: three independently established NPG-ESC lines; J1 and C57/B6: mouse ESC lines; CiPS: chemical induced pluripotent stem cell line; MEF: mouse embryonic fibroblasts) (E) Growth curve of 2 NPG-ESC lines, 1 ESC line and 1 CiPSC line.
We extracted a list of potentially problematic genes for human based on similar criteria, and being a little bit more conservative, i.e. only genes which are expressed in a maximum of 1 ESC line present in our study (see supplementary File S4).
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These mice were divided into nine groups according to the weight: control (saline), solvent (10%DMSO), 20 mg/kg 5-Fu, 4.5 mg/kg ESC, 3.0 mg/kg ESC, 25 mg/kg ESC-1, 16.75 mg/kg ESC-1, 1.5 mg/kg ESC-2, 1.0 mg/kg ESC-2.
Figure 23 ESC incorporation in ELAN environment.
Figure 21 ESC training for annotation.
Figure 12 ESC qualitative results on GSL using geometrical features.
Figure 13 ESC qualitative results on GSL using LAAMs features.
Figure 11 ESC qualitative results on GSL using GAAM features.
Figure 22 ESC vs. supervised classification with scrambled manual annotations.
Figure 17 ESC subject independency on the IMM database.
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