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Examples are shown in Table 1 (entries 1 3).
Fig. 7 Fixed number of 1 entries per row.
Unfortunately, no cyclized product was detected under various conditions (Table 1, entries 1 3).
In these cases, the highest yields were obtained (Table 1, entries 5 7).
Reaction time and temperature were varied, with little effect on RCY (Table 1, entries 4 8).
A few selected data are shown in Table 1 (entries 8 to 10).
Interestingly, fewer Top 1 entries and higher median/mean ranks were observed for the challenges with moderate candidate numbers (200 1000 candidates); lower median ranks and more Top 1 entries were observed for lower and higher candidate numbers.
When the weak bases (Et3N or K2CO3) were subjected, no spirooxindole product was generated (Table 1, entries 13 and 14).
[18F]afatinib demonstrates a slightly higher tumor-to-background ratio than [11C]erlotinib (Table 1, entries 3 and 6).
This couples technology developed through Crosscite [18, 19] with the DataCite Content Resolver (Table 1, entries 5, 10).
As expected, the MSS and FeCo/GC@MSS did not exhibit any catalytic activity (Table 1, entries 9, 10).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com