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Since, in a previous study on hysterectomy specimens, atrophic background endometrium was found to be an independent prognostic factor for patients with grade 1 EEC [ 6].
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In large-scale population study on 244 EEC patients, WNT7A overexpression was found in most cases of endometrial cancer in comparison with normal endometrium and benign endometrial lesion [ 46].
The study group comprised 103 EEC patients who underwent total abdominal or radical hysterectomy plus bilateral salpingo-oophorectomy with or without lymphadenectomy during a 5-year period at the University of Fukui Hospital (Fukui, Japan) (Table 1).
By immunohistochemistry, TFF3 protein was significatively more expressed in EEC compared with NE (P<0.01), with cytoplasmatic positivity in 79% G3-EEC and 18% NE.
This means that they are in accordance with the Belgian Royal Decree of 14 November 1993 concerning the protection of laboratory animals and the European Directive 86-609-EEC.
We analysed CA125 serum levels in 25 G3-EEC pandents and 42 controls tested with TFF3 ELISA.
In conclusion, TFF3 is highly expressed at gene and protein level in G3-EEC.
A total of 229 uterine sarcomas, 244 MMMTs, 7623 EECs, and 28 829 controls were available for this pooled analysis.
Importantly, as TFF3 is a secreted peptide, it may represent a novel, potentially useful diagnostic biomarker in G3-EEC patients.
This study identifies the genetic fingerprint of poorly differentiated endometrioid endometrial carcinomas (G3-EEC) and analyses the potential utility of trefoil factor 3 (TFF3) as novel serum marker in G3-EEC.
In contrast, Type II ECs include poorly differentiated endometrioid endometrial tumours (G3-EEC), serous papillary, and clear cell ECs.
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