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In particular, miR-1 and miR-133b have undergone a significant downregulation at 1 dpa.
In contrast, at 1 dpa, a strong marking of the epicardium at the level of whole-heart was observed.
Cavities were observed after irradiation doses of 10 and 20 dpa, but not after 1 dpa.
Particularly, miR-1, miR-133a and miR-133b have been detected in 1 dpa in different data sets of down-regulated transcripts.
Moreover, miR-133a is probably a key miR that can activate the epicardium because it showed a more significant downregulation already at 1 dpa.
The faulted loop density increased with dose from 1 dpa up to 10 dpa where it saturated and remained approximately the same until 20 dpa.
The faulted loop average diameter decreased between 1 dpa and 10 dpa and again remained approximately constant from 10 dpa to 20 dpa.
Additionally, they were irradiated using 3.2 MeV protons at temperatures from 200 to 500 °C to doses up to 1 dpa.
A structural transition with an increased c lattice parameter and a decreased a lattice parameter occurs after irradiation to doses above 1 dpa.
The three samples irradiated to doses above 1 dpa have comparable lattice parameters, hardness and modulus values, suggesting a saturation of irradiation effects in Cr2AlC.
Comparison of expression of genes between 1 dpa fiber and 1 dpa ovules identified 248 transcripts that were down regulated in 1 dpa fiber and 376 transcripts that were up regulated in 1 dpa fiber.
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CEO of Professional Science Editing for Scientists @ prosciediting.com