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In patients who have ≥ grade 3 diarrhea, the dose of 5-fluorouracil is decreased by 1 dose level.
A single ascending dose design with 8 dose levels was used.
The dose of irinotecan was escalated in serial cohorts at 3 dose levels: 80, 90, and 100 mg/m2 on day 1.
Multiple doses of ISIS-SMNRx (3 dose levels) were delivered by intrathecal injection to medically stable SMA patients 2 15 years of age (n = 25).
The 3 dose levels of the malaria vaccine had acceptable tolerability.
At the 8 and 16 mg kg−1 dose levels, Cmax and AUCs were increased, and total clearance was reduced, suggesting saturable elimination.
After two out of five patients had DLT at the 75 mg kg−1 dose levels, 60 mg kg−1 was defined as MTD.
MX-1 tumour-bearing mice were treated p.o. with various (i.e. 30, 60 and 90 mg kg−1inj−1) dose levels of IDN 5390, twice a day (2 ×), starting when tumours averaged 100 mg.
Total lipid content of the semitendinosus (ST) muscle and mesenteric adipose tissue was reduced (P<0.01) in both 5 mg/kg and 10 mg/kg BW C16:1 dose levels.
At the 30 and 60 mg kg−1 dose levels, the median baseline VPA concentrations were in the range, normally achieved during anti-epileptic therapy (50 120 mg l−1; Figure 1A).
Total lipid content of the ST muscle and mesenteric adipose tissue was reduced (P<0.01) in both 5 mg/kg BW C16:1 and 10 mg/kg BW C16:1 dose levels.
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