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Fig. 1 Deficient autophagy in critically ill patient PBMCs.
In the present study we found no defects in telomere length maintenance in tankyrase 1 deficient mice.
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Moreover, GCK-1 deficient animals display a significant increase in germ cell death.
This activity was validated in hepatocellular tumors induced in nm23-1 deficient mice.
To this end, syndecan-1 deficient mice were subjected to the experimental metastasis model.
The mechanism for enhanced APC activity in SHIP-1 deficient cells is under investigation.
Interestingly, the CD11bhiF4/80hi macrophages were completely missing in CSF-1 deficient mice.
We gratefully acknowledge Dr. M Götte (Medical Center, University of Münster, Münster, Germany) for the syndecan-1 deficient mice.
One could suggest that reduction of those mediators might contribute to wound healing impairment observed in HO-1 deficient mice.
In contrast to our data, this paper found that Casp-1 deficient mice had decreased survival during Mtb infection.
We found the reduced concentration of soluble CD40 antigen and IL-17 in HO-1 deficient mice.
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