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For example, in breast cancer, PARADIGM ranks 1 decoy in the top 10, 2 in the top 30 and 4 in the top 50.
It can bind to four membrane-bound receptors and one soluble receptor (TRAIL-R1, TRAIL-R2, TRAIL-R3, TRAIL-R4 and osteoprotegerin also known as DR4, DR5, decoy receptor 1 (decoy, decoy receptor 2 (DcR2) and OPG, respectively).
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Indirect interactions are often described by the Guard [ 4, 6] or Decoy [ 7] models.
Upregulation of IL-1 decoy receptor CD121b is one hallmark of GCsM.
Furthermore, also GMaM upregulate the IL-1 decoy receptor CD121b [16].
In balanced redox homestasis, prolonged activation of monocytes leads to more increased production of counterbalancing IL-1RA (IL-1 receptor antagonist) and upregulation of IL-1 decoy receptor CD121b (IL-1R-type II).
The transcription factors STAT3 and STAT6 allow for high-level production of the cytokines IL-10, IL-1 receptor antagonist (IL-1Rα), IL-4Rα, TGF-β, and the type II IL-1 decoy receptor [16],[16],[16],[16].
The recently completed clinical trials of edifoligide (E2F decoy oligodeoxynucleotide) provide important lessons for future studies.
The DuD database consists of more than 95,000 decoy structures and 2,950 ligand structures (more than 30 decoy structures per ligand) for 40 protein targets including HMGR.
To generate a total of 100 decoy sets, MODELLER was used with the selected template structure.
Immunohistochemistry and Western-blot analysis revealed that Smad/Sp1 chi decoy ODN showed a more significant inhibitory effect on fibrosis and EMT compared with Smad and Sp1 decoy ODNs.
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