Exact(4)
One patient stopped trastuzumab after 50 cycles because of grade 1 decline of LVEF.
Two patients stopped treatment because of grade 2 decline of LVEF and one patient because of grade 2 liver toxicity concomitant with a grade 1 decline of LVEF.
34 Secondary outcomes were (1) decline in discharge status, (2) critical care consultation, (3) organ failure and (4) hospital length of stay.
In the multivariate analysis 2 gains (verification of how the patient takes ART and assessing potential drug interactions) and 1 decline (assessment of adverse reactions) remained significant.
Similar(56)
Objective: In aging men serum levels of testosterone and insulin-like growth factor-1 (IGF-1) decline, potential factors in the reduced muscle strength, abdominal obesity, sexual dysfunction and impaired general well being of aging.
Remarkably, after accelerated degradation test through 2000 cyclic voltammetry, the mass activity for Pt/TiO2@RFC was well maintained at 689.5 mA mg−1, 3.3 times that of the commercial Pt/C (206.1 mA mg−1, decline of 40.17%).
Maybe the next 50 1 decline will happen faster.
In humans, serum GH and IGF-1 decline gradually from ∼30 years of age [20], [21], while in mice serum IGF-1 levels remain fairly constant [22].
In females this association was less evident, however the A-allele carriers had a faster plasma IGF-1 decline over age than the G/G subjects.
Also, addition of NAC during glucose deprivation did not prevent Mcl-1 decline (Fig. 6c, d), while it was capable of completely abrogating the pro-apoptotic effects [ 34] of CCCP (Fig. 6e).
On exposure to silvestrol or HHT, the levels of pro-survival Mcl-1 decline rapidly (Supplementary Figure 5a) and it has been proposed that this is the key process for inducing apoptosis.
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