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Among 14 serum and 21 cerebrospinal fluid (CSF) samples obtained from 28 patients with clinical suspicion of TBEV 1 CSF sample tested positive for TBEV RNA.
In addition, 14 saliva samples and 1 CSF sample were obtained from surviving patients.
Eight of the 14 saliva samples and 1 CSF sample were confirmed as positive for RABV RNA.
The presence of lineage 2 WNV RNA was identified in 1 CSF specimen and confirmed by sequencing (GenBank accession no. JX974605).
Retrospective analysis of a day 1 CSF sample revealed that more timely identification of Balamuthia by metagenomic NGS, potentially resulting in a better clinical outcome, would have required availability of the complete genome sequence.
In addition, it is highly unlikely that 18S PCR sequencing would have been positive in the patient's day 1 CSF given the absence of Balamuthia 18S sequences in the case patient's metagenomic NGS data (Fig. 5b).
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To investigate the expression and regulation of colony-stimulating factor 1 (CSF-1) and its receptor, C-FMS, in endometriosis.
Lacking any discernible sequence similarity, interleukin-34 (IL-34) and colony stimulating factor 1 (CSF-1) signal through a common receptor CSF-1R on cells of mononuclear phagocyte lineage.
This pair of cell lines represents a simple model system for intercellular communication: the LADMAC cells produce colony-stimulating factor 1 (CSF-1), which is required by the BAC cells for survival.
To investigate the role(s) of colony-stimulating factor 1 (CSF-1) on the development of early endometriosis in a murine model by comparing rate of lesion formation in mice [1] homozygous for a CSF-1 mutation versus syngeneic controls and [2] after treatment with imatinib, a commercially available tyrosine kinase inhibitor that alters interaction(s) between CSF-1 and its receptor, c-fms.
LADMAC cells secrete the growth factor colony-stimulating factor 1 (CSF-1).
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