Sentence examples for 1 cpg from inspiring English sources

Among the important findings about CpG islands are: (1) CpG islands tend to co-localize with the transcription start sites (TSS) of genes [ 1, 2]; (2) promoter CpG islands are usually unmethylated (CpG island methylation is strongly associated with reduced gene expression) [ 1, 2]; and 3) treatment of methylated CpG islands with methytransferase inhibitors generally increases gene expression [ 3].

Even-skipped homeobox 1 CpG islands and the gene regions assayed are detailed in Figure 1.

Surprisingly, 3T3-L1 cells had significantly lower methylation levels than HIB-1B cells at CpG 1, CpG 4 and CpG 6 (p < 0.05) (Fig.  2b).

The human IL1B promoter contains 7 CpG sites in the 900-bp sequence upstream of exon 1 and 1 CpG site within exon 1 [GenBank: AY137079].

With enrichment for methylation, reads will align particularly to the 2.66 M locations containing at least 1 CpG site within 50 bp of the cut site.

As shown in Figure 2C, there are 11 CpGs, encompassing a region of 800 bp containing the 3' end of DNase I hypersensitivity site (HSS) 1 (CpG site 1) and all of HSS2 (CpG site 5-11).

Mammalian gene promoters are known to fall into one of at least two major classes: 1) CpG-rich promoters are associated with both ubiquitously expressed 'housekeeping' genes, and genes with more complex expression patterns, particularly those expressed during embryonic development and 2) CpG-poor promoters are generally associated with highly tissue-specific genes.

All 13 CpG sites were located within CpG islands.

The vast majority of this methylation occurs in regions of low CpG density (∼1 CpG per 100 bp) [4], [21] yet interspersed in this sea of low-density methylation are select regions such as CpG islands (CGIs) with higher CpG content and more variable methylation [1].

The means of the triplicate methylation fractions (MMFs) were examined, only the readouts with standard deviations < 0.15; therefore, 8 of 72 CpG sites were excluded for a total of 64 CpGs comprising 36 CpG units.

Of 36 CpG units, 6 CpG units differed nominally in MMF between cases and controls; 5 CpG units' MMFs, mostly in amplicon D3 (promoter 5), remained significant following FDR.