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C3 levels were measured in 32 individuals with AAMD and a CFI variant associated with low FI levels (type 1 CFI mutation) and 13 individuals with grade 1 only and no CFI variants.
Type 1 CFI mutations accounted for 42% of the AAMD group but only 6% of the non- AAMD group.
Only three individuals with a type 1 CFI mutation had low C3 levels (Supplementary Material, Fig. S3).
The 3-factor model somatic complaints, negative affect, and emotional numbing fit the two confirmatory samples reasonably well (CFI = .918, TLI = .946, RMSEA = .061 in confirmatory sample 1; CFI = .929, TLI = .947, RMSEA = .056 in confirmatory sample 2).
The 3-factor model suggested by the EFA fit the two confirmatory samples adequately (CFI = .943, TLI = .974, RMSEA = .087 in confirmatory sample 1; CFI = .920, TLI = .959, RMSEA = .099 in confirmatory sample 2).
There was a positive correlation between the levels of FI and C3 in these 32 individuals with a type 1 CFI variant (R = 0.51, P = 0.003) (Supplementary Material, Fig. S4).
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The fit statistics for the saturated model were acceptable: x2 =386.6197197 df, CFI = 0.95, RMSEA = 0.05, NNFI = 0.90.
However, candidate gene sequencing did not reveal mutations in F2, F5, CFH, CFI, MCP, ADAMTS13 and NPHS2.
Ratio X 2/df under 2, a CFI over.90 and a RMSEA under.10 indicate good fit (Bollen, 1989).
19, 20, 28 The CFI exceeded the threshold value.
For homozygous and heterozygous cats the odds ratios were found to be 21.6 (95% Cfi: 7.0; 66.2) and 0.5 (95% Cfi: 0.1; 2.3), respectively.
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