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Less is known about genetic variation's role in individual psychobiological responses to partnering and fathering, particularly as related to T. We examined the exon 1 CAG (polyglutamine) repeat (CAGn) within the androgen receptor (AR) gene.
To the best of our knowledge, this is the first study that has examined the Androgen Receptor exon 1 CAG repeat variation in RSA.
The exon 1 CAG repeat was analysed as previously reported [ 44].
The androgen receptor (AR) gene exon 1 CAG repeat polymorphism encodes a string of 9 32 glutamines.
There is not any single sequence that occurs more frequently than others, except pattern 5, which occurs 3 times by losing 1 CAG directly from the parental sequence.
The AR exon 1 CAG repeat polymorphism does not appear to have an effect on breast cancer risk in BRCA1 or BRCA2 mutation carriers.
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Of the 60 biopsy-samples examined, 10 were diagnosed as normal, 15 as CSG, 9 as CAG, 16 as IM with CAG, and 10 as DYS (Table 1).
SBMA AR100 mice carry 100 CAG repeats in the AR gene as determined by Sanger sequencing.
For instance, the distance between the two alleles in sample NA13506 (15 and 48 CAGs, 446 bp and 545 bp) and NA13512 (16 and 46 CAGs, 449 bp and 539 bp) appeared to be comparable (panels D-E in Fig. 6), as expected from the similar size difference of 33 and 30 CAG repeats, respectively.
For sample GM14044, which contains one allele with 19 CAGs and a longer and more heterogeneous expanded allele averaging ~750 CAG repeats (Supplementary Fig. S7), we could only detect the shorter allele using these initial conditions (Fig. 6F).
This tendency is especially true in cases of juvenile HD, where most individuals have between 80 and 100 CAG repeats.
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