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Then the values for the cases were shifted by Φ - 1 (AUC 0 ) · σ 0 2 + σ 1 2 to obtain the true AUC (AUC0).
As shown in Figure 1, AUC and the log P value exhibited inverse linear correlations, indicating that both AUC and P values were important parameters for the selection of effective biomarkers.
Table 1 AUC scores and scaling parameters for all data sources and their combinations.
Table 1 AUC for power and SNR features as a function of SNR.
Fig. 1 AUC for the MM cohort considering all genotype SNPs (a) and only those SNPs that individual exhibit a nominal level of significance (b).
In what follows (Table 1), AUC denotes the "area under the (ROC) curve (false positive rates from 0 .2)" and TPR is the "true positive rate" at a fixed a false positive rate of 0.05.
Similar(31)
Before ranking, AUC values for genes with negative correlation, and hence showing AUC values <0.5, were inverted to values >0.5 by assigning AUC = 1-AUC.
The glucose area under the curve (AUC) was calculated according to the following equation [ 16]: (1) AUC = 0.25 (fasting ) + 0.5 (1 2 hr value ) + 0.75 (1 hr value ) + 0.5 (2 hr value ).
If AUC < 1/2 the covariate x is however negatively correlated with z, and replacing x by - x turns AUC into 1-AUC (which will be >1/2).
When testing the performance of a gene signature in independent validation data only the genes were used in the validation data, i.e. not the information on AUC and 1-AUC or the classification threshold.
Total GLP-1 AUC was similar after all three oral stimulations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com