Sentence examples for 1 attenuate from inspiring English sources

Based on our current understanding of PD pathogenesis and mitochondria-related mechanisms of cell death, neuroprotective drugs can be divided into drugs that (1) attenuate mitochondrial apoptosis, (2) reduce oxidative stress in mitochondria or (3) directly target mitochondrial function (Fig. 5).

A novel finding of our study is that Hispanic subjects were the only group with both pancreatic and hepatic steatosis, the latter being known to 1) attenuate insulin-mediated suppression of gluconeogenesis, elevating fasting plasma glucose and basal insulin secretion; and 2) augment hepatic TG secretion, exposing the pancreas to a higher TG load (29, 30).

XA21 also recruits a protein phosphatase 2C, XB15, to attenuate XA21 signaling [13], [16].

With regard to the role of PDE3B activation in response to insulin, it has been shown that leptin and IGF-1 attenuate insulin secretion in a PDE3B-dependent manner in HIT-T15 cells [6], [36].

Although knock-downs of SF-1 [38] and SGK-1 attenuate the ATR response on some target genes, overexpression of SGK-1 and/or SF-1 are insufficient to induce an ATR response in non-responsive cell lines (Fig 5A and data not shown).

Reduced levels of IGF-1 attenuate both general growth and SG growth and lipid synthesis 13– 17. Cell growth is controlled by cell cycle inhibitors.

There is also preliminary evidence that Peptide YY (PYY) and GLP-1 attenuate activity in the amygdala, OFC, caudate, accumbens and insula, when viewing high calorie food pictures in the fasted state [48].

Fibroblasts overexpressing angio-poeitin-1 attenuate endotoxin-induced lung injury [ 40], while fibroblasts overexpressing vascular endothelial growth factor and endothelial nitric oxide synthase can attenuate or even reverse endotoxin-induced ALI [ 68].

In addition, we show that Ets-1 is required for the TGFβ induction of CCN2, as dominant negative Ets-1 and siRNA recognizing Ets-1 attenuate the ability of TGFβ to induce the CCN2 promoter activity and protein expression in fibroblasts.

Its latest efforts consist primarily of a long poem, in a typewriter font, displayed 10 sheets at a time under Plexiglas on 13 attenuated tables, and 38 photographs in black and white and color of wan young models in jeans.

TGF-β1 attenuated CCI-induced thermal hyperesthesia in rats.