Sentence examples for 1 activating from inspiring English sources

Additionally, PCAF can acetylate lysines on non-histone proteins such as tumor protein p53 and retinoblastoma 1, activating their tumor suppressor activity [10], [11].

A pre-annealing step at 500 °C for 0.5 hour was proposed and found to be crucial for three functions: (1) activating implanted nitrogen ions; (2) repairing the lattice damage; and (3) cleaning the sample surface.

Therefore, the teacher, the students and the teaching assistants were encouraged to use Twitter frequently with the aim to reach the following objectives: 1) Activating prior knowledge about lesson topics.

They also mimic the effects of α2-macroglobulin on the upregulation of GRP78 and X-box binding protein 1, activating transcription factor 6 α, and serine/threonine-protein kinase/endoribonuclease precursor α as endoplasmic reticulum stress biomarkers and show no effect on expression or activation of caspases 3, 9, or 12.

To tackle the challenges, at least two processes should be realized: (1) activating the intrinsic chemical inertia of PTFE via breaking the ultra-stable C F bonding, (2) providing sufficient bonding sites to fix TiO2 tightly via surface functional groups [9, 10, 11].

We repeated the experiment shown in Figure 1, activating cells with hyperosmotic sorbitol to activate p38, and subsequently treating cells with hydrogen peroxide to inhibit p38 (Figure 3).

Agonist-induced platelet aggregation responses to ADP (adenosine diphosphate), epinephrine, collagen, arachidonic acid, and PAR-1 (protease-activated receptor-1) activating peptide, as well as spontaneous platelet aggregation, were significantly increased in patients with metastatic cancer.

As discussed above, a number of chemotherapy-induced molecular pathways can upregulate NKG2D and DNAM-1 activating ligands, able to increase activation and cytotoxic responses of NK cells toward MM.

Starting from the former case, we used the so-called phospho-mimicking effect of acidic mutations in close proximity to (just before, P−1, or after, P+1) activating phosphorylation sites on the activation segments of kinase domains (Davies et al., 2002) to identify in silico missense mutations that can result in a constitutively active kinase.

The IRS proteins are differential mediators of insulin action in liver, with IRS-1 activating PI3K and in turn leading to activation of Akt and stimulating PEPCK, resulting in increased gluconeogenesis.

These receptors have been demonstrated to be key proteins in the activation of pro-caspase-1, through the formation of the caspase-1 activating platforms, the inflammasomes.