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System 1 activates a sequence of automatic actions.
The signalling cascade downstream of angiotensin-receptor 1 activates PLC2β which signals to PKCα.
Ren2, a homolog of the endopeptidase Renin 1, activates the renin-angiotensin system, increasing blood pressure [ 26].
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We next addressed whether IRF-1 activates transcriptional activity at the PUMA promoter by luciferase reporter.
ET-1 activates other mitogen-activated protein kinases (MAPKs), c-Jun N-terminal kinases (JNKs) and p38-MAPKs, although these are activated more potently by cellular stresses.
Since Alda-1 activates both the dehydrogenase activity and esterase activity of ALDH2, Beretta et al. evaluated the effect of Alda-1 on bioactivation of nitroglyercin.
It has been shown previously that in breast cancer cell lines administration of CSF-1 activates cyclin D1, as a consequence of ERK1/2 activation [ 17, 24].
Angiopoietin-1 activates the Tie-2 signalling while angiopoietin-2 inhibits this activation.
We conclude that mIGF-1, but not IGF-1, activates at least some cardio-protective genes through SirT1-dependent activation of their promoters.
DMP-1 activates integrin signalling and is endocytosed into the cytoplasm whereupon it is translocated to the nucleus.
report that endothelial cell-derived endothelin-1 activates mesangial cells, which deposit abnormal laminin isoforms in the Alport glomerular basement membrane.
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