In the same study, overexpression of heterologous HAC1, the transcriptional activator of UPR in S. cerevisiae, clearly induced the UPR-regulated genes KAR2/BiP and PDI1.
MANF is upregulated by UPR in several mammalian cell lines [ 6- 8] and by ischemia induced UPR in the heart and brain [ 8- 10].
Here, we systematically analyzed the UPR in response to different stressors by measuring multiple aspects of secretory pathway function and UPR activation.
This Review summarizes these emerging noncanonical functions of the UPR in immunity.
Masciarelli, S. et al. CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells.
The requirement for GSH, NRF2 and UPR in alkylation survival was validated by metabolomics, protein studies and functional cell assays.
The detrimental effects of prolonged UPR in a myriad of diseases (reviewed in refs. 35,36) makes new druggable targets highly desirable (reviewed in ref. 37).
Consistent with our results, these findings suggest that the IRE1α-mediated UPR in immune cells might be involved in the regulation of joint inflammation.
Notably, the decreased secretory capacity present in CD8+ T cells in tumors47 rules out its role as a driver of UPR in TILs.
In this study, we showed that RES caused cell cycle arrest and proliferation inhibition via induction of unfolded protein response (UPR) in human leukemia K562 cell line.
Xue, X. et al. Tumor necrosis factor α (TNFα) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS -dependent fashion, and the UPROS -dependentROS accumulation by TNfashion
