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The Food and Drug Administration has not proposed classifying vitamins as drugs if their potencies exceed recommended daily allowances.
Although liposomes have proven useful for the delivery of drugs and gene therapy vectors, their potencies are often compromised by poor unloading following uptake into their target cells.
In functional assays Cl-IB-MECA and IB-MECA were able to inhibit cyclic AMP accumulation and their potencies were statistically increased after exposure to PEMFs.
Derivatives 21 and 22 proved to be the most active within the series and their potencies against AChE were in the same order of magnitude of the reference compounds.
Of the four antiepileptic drugs tested in this model, only phenytoin proved ineffective, while valproate, gabapentin and carbamazepine varied in their potencies, with only the latter drug proving to be completely efficacious.
Several new 5,6-dihydropyrimidine-2(1H -thione derivatives have been prepared and investigated for their potencies for anticonvulsant activity against maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) test in mice.
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Nevertheless, a good relationship exists between the potencies of analgesics in writhing assays and their clinical potencies.
The rank order of potency of these compounds for decreasing melanin content was different than their relative potencies as antidepressants.
Contrary to the lipophilicity, the basicity of alkylamidine compounds directly influences their antimalarial potencies.
Molecular docking provided insight into the binding mode of these inhibitors and rationalized their different potencies.
All these steroidal antedrugs exhibited concentration-dependent inhibition of NO production, but their relative potencies were lower than prednisolone.
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