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In AMAC [16], communication pairs exchange the prioritized channel list and select a different ND-CCC in the list.
We used these receptor-per-protein ratios to define a cut-off to select candidates from the prioritized list.
We found that transcription factors are prominently present among the prioritized candidate genes.
We were therefore unable to establish a causal link between the prioritized functional SNP and the LPP gene.
We applied this approach to measure if the prioritized hub genes are more enriched in GO terms or involved in pathways than what would be expected by chance.
Since the prioritized SNP rs4686484 has a regulatory function, it may affect other genes outside of the LD block as well.
An important question with respect to the prioritized candidate genes is whether these have any special properties which make them a priori more likely to be causal genes.
Such links between the prioritized genes and the homologous recombination pathway would implicate that some of these genes are connected with recombination hotspots.
Nevertheless, 37 of the prioritized candidate genes were in the neighborhood of significant SNPs identified by GWAS; these involved 6 of the 12 traits.
No more wondering what comes next — your team can simply pull work from the top of the prioritized list.
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The damning report found that the city prioritized aggressive revenue collection over public safety.
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CEO of Professional Science Editing for Scientists @ prosciediting.com