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The plots reveal that the leverages of bulk of the molecules do not go beyond the caution value (h*) in the QSAR models and thus the applicability of the models is reasonable.
This is achieved by using the leverages h i from the mean part of the model.
Moreover, the leverages can be a useful tool to identify important aspects of data imbalance (as shown in Figure 1).
Including the leverages in the fitting procedure is important to obtain acceptable variance component estimates in animal models and also for imbalanced data.
So, the leverages h are equal to W asreml ·h asreml where W asreml is the diagonal matrix of prior weights specified in ASReml and is the estimated residual variance.
The effects of adjusting for the leverages, or not, are similar to the effects of using REML instead of ML to fit mixed linear models, where ML gives biased variance component estimates and the estimates are more sensitive to data imbalance [ 12].
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"Now it is a question of using the right leverages to get the best out of them on Thursday.
In Act III the performer leverages celebrity into ownership of the business.
Then, the platform leverages predictive analytics to forecast bestsellers.
And then the acquirer leverages those extra lines by discounting its dominant product to produce a lower-priced package deal.
Second, the framework leverages model checking to validate adaptive Breeze/ADL specifications.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com