That the expression of one TCR in dual TCR T cells can be reduced or lost was reported previously 23262326
Our results reveal a critical role for the TCR in the suppressor capacity of Treg cells.
Levine, A. G., Arvey, A., Jin, W. & Rudensky, A. Y. Continuous requirement for the TCR in regulatory T cell function.
Constitutive ablation of the TCR in TracFL/FLFoxp3YFP-Cre mice impairs Treg cell population expansion and precipitates early-onset autoimmunity.
A combination of factors is necessary to place the modified TcR in an optimal functional window.
Indications for and timing of tethered cord release (TCR) in LMM are therefore controversial.
Mikszta, J. A., McHeyzer-Williams, L. J. & McHeyzer-Williams, M. G. Antigen-Driven Selection of TCR In Vivo: Related TCR α-Chains Pair with Diverse TCR β-Chains.
The role of the T cell receptor (TCR) in antigen recognition and activation of T lymphocytes is well established.
These results demonstrate that CRAC channels provide the major, if not sole, pathway for Ca(2+) entry activated by the TCR in human T cells.
These studies show for the first time that SLP-76 is required for signal transduction through the mature alphabeta TCR in primary cells of the T lineage.
can ensure the TCR in a range from ± 2 ppm K− 1 up to the negative value of − 60 ppm K− 1.
