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Efflux of SSG in SSG-unresponsive parasites has been attributed to similar cellular processes [56].
In this study we evaluated a new therapeutic approach with cationic liposomal SSG against SSG-resistant L. donovani parasites.
Cure due to elevated accumulation of SSG in intracellular parasites, irrespective of SSG-resistance, occurs as a result of increased drug retention and improved therapy when administered as PC-SA-SSG versus free SSG.
SSG resistance in Leishmania involves reduction in intracellular SSG accumulation, either as a result of its reduced influx or increased efflux from the parasite and/or macrophages [4].
The ex situ formation of seeds in SSG makes the technique time demanding than the PPH used in this study and SSG technique always produces "thin-film" membranes.
Once experts had produced draft assessments, SSG staff circulated summaries (comprised of rationales, Red List Categories and Criteria) to the entire SSG network for comment.
Earlier we reported a profound synergistic activity of SSG entrapped in PC-SA liposome in both in vitro and in vivo models of SSG-non-resistant VL [29].
SGT Scorzelli + SSG Scorzelli.
The prisoner was no danger to SSG Frederick...
"How many deployments has SSG Gibbs had?" investigators asked.
But the SSG will still visit her, members have vowed.
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