The memos emphasized a potential risk called QT prolongation, in which the heart delays recharging electrically.
As expected, application of IKur blocker produced pronounced action potential duration (APD) prolongation in atrial myocytes.
Thus specific T cell responses appear to mediate viral-elicited prolongation in survival.
Balancing these serious risks against the potential benefits including life prolongation in the final phase of someone's life must be a near impossible task for an oncologist.
By contrast, the pmif RNA replicon immunized mice showed better control of parasitemia during the first 15 days of infection and a 37% prolongation in mean survival time.
This syndrome is characterized by a prolongation in the depolarization time-course of cardiac myocyte action potentials, which can lead to fatal arrhythmias.
After edrophonium, the maximal prolongation in P-P (118%, p < 0.01) and PQ (120%, p < 0.01) intervals was the same.
The prolongation in the P-P interval (11%, average 85 msec) and PQ duration during atrioventricular block disappeared immediately after the restoration of atrioventricular conduction.
No prolongation in the linear corrected QT interval was observed in cetirizine-treated infants compared with either baseline values or with values in placebo-treated infants.
Blockade of the delayed rectifier potassium channel current, IKr, has been associated with drug-induced QT prolongation in the electrocardiogram and life-threatening cardiac arrhythmias.
Compared to the initial lead 2, compound 28 exhibited reduced potential for QTc prolongation in a non-human primate cardiovascular safety model.
