Sentence examples for * pbpk from inspiring English sources

We developed a child-specific PBPK model for CPF using PBPK models previously developed for rats and adult humans.

Section 2 covers applications within the pharmaceutical industry, the integration of PBPK with pharmacodynamics, as well as PBPK modeling of populations; it finishes with a short chapter on the use of PBPK in drug discovery and development.

Model refinement may be completed throughout the adult PBPK model development process, and the final adult PBPK structure and drug-specific inputs are held constant in pediatric PBPK model creation.

Within the pediatric PBPK model development process, allometric principles are innately incorporated since PBPK models define organ size/volume using age-dependent relationships.

However, current limitations in PBPK modeling in particular, the need for prospective validation of PBPK models for their intended use in pregnancy need to be addressed.

An alternative approach which utilizes the mechanistic nature of PBPK models is the incorporation of population-based simulations (Pop-PBPK).

For instance, since 2001, there have been several additional TCE-specific PBPK modeling efforts as well as more general methodologic advances in characterizing PBPK model uncertainty and variability.

Jan Snoeys (Janssen) provided an overview of PBPK in drug development and two additional presenters gave specific examples of the use of PBPK in industry.

Since different solutes have different sensitivities to the different PBPK parameters, using a variety of solutes to optimize the parameters increases the validity of the PBPK.

Build a physiologically based pharmacokinetic (PBPK) model for human handling of PFOS that could explain uptake, clearance, and distribution and exposure pathways by reverse PBPK modeling.

The PBPK modeling was utilized for the virtual bioequivalence study.