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I have never been on a tricyclic (which chiefly affects the neurotransmitters serotonin and norepinephrine) or on an MAO inhibitor (which influences serotonin, norepinephrine, and dopamine).
Dr. Liggett knew that genes controlling the hormone norepinephrine make the heart pump more blood.
In any case, too much norepinephrine seems to play a major role in hot flashes.
The drugs weaken the heart's response to the fight-or-flight hormones epinephrine and norepinephrine.
Scientists suspect that by increasing norepinephrine levels, modafinil may block the region from promoting sleep.
Like some antidepressants, it helps prolong the action of two brain chemicals, serotonin and norepinephrine.
Depression is associated with decreased activity of important neurotransmitters like serotonin and norepinephrine.
"Modafinil might activate dopamine, which then activates norepinephrine, which then activates histamine, for example.
Substances like serotonin, dopamine and norepinephrine play crucial roles in learning, updating memories and neuropsychiatric disease.
New experiences activate the brain's reward system, flooding it with dopamine and norepinephrine.
Apparently, it's the interaction of brain chemicals norepinephrine and dopamine that gives rise to the phenomenon.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com