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From m-NP, TouA mutant I100Q produces 4-NC (37%) and NHQ (63%), whereas wild-type ToMO produces only 4-NC (100%).
It was also discovered that wild-type ToMO forms 4-nitrocatechol (4-NC) from m-NP and p-NP with an initial rate of 0.15 and 0.0082 nmol/(min mg protein), respectively, and 3-NC (12%) and nitrohydroquinone (NHQ, 88%) from o-NP with an initial rate of 0.11 and 0.8 nmol/(min mg protein), respectively.
Following the 1974 Smiling Buddha nuclear test, the Director of Marine Engineering (DME) at Naval Headquarters (NHQ) initiated a technical feasibility study for an indigenous nuclear propulsion system (Project 932).
Following the administration of systemic antibiotics, plasma 2-heptyl-4-hydroxyquinoline (p=0.02) and NHQ concentrations (p<0.01) decreased significantly.
Plasma concentrations of 2-nonyl-4-hydroxy-quinoline (NHQ) were significantly higher at the start of a pulmonary exacerbation compared to clinical stability (p<0.01).
An early study using GC and electron capture MS identified over 20 different AQs (Taylor et al., 1995), with HHQ being the most prevalent, followed by NHQ.
Using ozonolysis and UV absorption spectra in comparison with synthetic standards, Wells et al. (1952) identified Pyo Ib as 2-heptyl-4(1 H -quinolone (H -quinolone as 2-nonyl-4(1 HHQquinolone (NHQ) and Pyo IcI as a monounsaturated alkyl side chain variant of NHQ (Wells, 1952; Wells et al., 1952;).
At the start of the pulmonary exacerbation, sputum, plasma and urinary levels of HHQ, NHQ and HQNO were positively correlated with each other in all three biofluids (table 3).
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NHQ correlates with clinical status and has potential as a novel biomarker for P. aeruginosa infection.
> -wrap-foot> Following the administration of antibiotics, plasma concentrations of HHQ and NHQ decreased significantly (table 2).
The surgical procedure was recorded according to the Nordic Classification of Surgical Procedures (codes NEQ 19 NHQ 14) and included amputation level, side, and diagnosis.
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