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Therefore, our results suggest that CXCR4, as a receptor for MIF in urothelial cells, may contribute to MIF-mediated bladder inflammation.
Chemical or lipopolysaccharide-induced cystitis was found to induce increases in the protein levels and mRNA expression of MIF in nervous system structures innervating the bladder suggesting a role for MIF in bladder inflammation [ 7, 8].
To elucidate the role of MIF in MMP-2 production, we produced zymosan-induced arthritis (ZIA) in MIF gene-deficient and wild-type mice.
Understanding the role of MIF in neoplastic development and progression is complicated by the pleiotropic influences that MIF plays in many tumorigenic processes.
These data highlight the importance of MIF in the development of autoimmunity and support the potential clinical feasibility of pharmacologic MIF antagonism.
In view of previously published work suggesting a role for MIF in the expression level of TLR4 [30], [30], these results suggest an association between TLR4 and MIF in patients with autoimmune disease.
MIF was six fold higher in gouty SFs compared to osteoarthritic fluids, suggesting the importance of MIF in gouty arthritis.
Increased thickness of the MIF in Figure 1c also does not indicate the decreased size of the nanoparticles.
Objectives: To study the role of macrophage migration inhibitory factor (MIF) in the pathogenesis of alcoholic liver diseases.
It is seen that the value of bending stress calculated at any depth of beam is more in case of MIF in comparison to bending theory and FEM.
To quantify levels of macrophage migration inhibitory factor (MIF) in the peritoneal fluid (PF) of women with endometriosis, and to correlate these levels with the extent of disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com