Exact(12)
Junín virus infection of human hematopoietic progenitors impairs in vitro proplatelet formation and platelet release via a bystander effect involving type I IFN signaling.
Moreover shRNA-mediated knock-down experiments confirmed our observations by showing that silencing CXCR4 in NB cells impairs in vitro and almost abrogates in vivo growth.
Endotoxemia impairs in vivo and ex vivo MGU in addition to cardiac output.
Moreover, metformin impairs in vitro GBM CSC self-renewal, as measured by spherogenic activity.
Taken together, these findings demonstrate that genetic deficiency of PI3Kβ impairs in vitro development and resorptive function of osteoclasts.
Of note, we documented the reconstitution of miR-204 expression impairs in vitro and in vivo the tumor potential of GC cell lines.
Similar(48)
The demonstration that disrupting glutamatergic neurotransmission within a hippocampal-prefrontal system impairs object-in-place memory in rats, accords with these studies.
Although PAI-1 is dispensable for lymphangiogenesis, it is worth noting that other proteolytic systems are mandatory for this process and particularly matrix metalloproteases such as the MMP-2 whose deficiency impairs lymphangiogenesis in in vitro and in vivo models [29].
However, cavitation erosion considerably impairs the in-service performance of ultrasonic sonotrodes, leading to marginal microstructural refinement.
Moreover, infusion of ZIP (myristoylated PKMζ pseudosubstrate peptide), a peptide that interferes with atypical protein kinase C activity, so as to be active during acquisition and early consolidation impairs object-in-place memory if infused into medial prefrontal cortex but not if infused into hippocampus or perirhinal cortex [106].
Stress facilitates eyeblink conditioning in male rats, but impairs it in female rats especially in the diestrus phase (Bangasser and Shors 2008; Hodes and Shors 2007; Leuner and Shors 2006; Wood et al. 2001; Wood and Shors 1998).
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