Exact(17)
Canakinumab was shown to be effective in treating pediatric patients with colchicine-resistant FMF in this study.
The prevalence of FMF in Armenia and in Karabakh, a region close to Armenia inhabited by Armenian people, is particularly high ranging from 0.5 to 1.5% [11].
We performed genotyping of the exon regions of the MEFV gene, which is thought to be a single genetic determinant of FMF, in particular exons 2 and 10, where the majority of disease-associated mutations were identified (http://fmf.igh.cnrs.fr/infevers).fr/infevers
Given the prevalence of FMF in Karabakh (∼0.01) and the frequency of the alpha/alpha genotype in this area (∼0.1), the expected percentage of Karabakhian alpha homozygous FMF patients is very low (at most 1.10−3); a negative selection could, therefore, easily pass unnoticed.
In addition, we described the clinical manifestations of FMF in 80 Japanese patients [ 14].
The first case of FMF in association with AS was described in 1963 [ 30].
Similar(43)
In particular, in asymptomatic FMF patients in remission, the proportion of Enterobacteriaceae, Acidaminococcaceae, Ruminococcus and Megasphaera was significantly increased in comparison with control subjects, while Roseburia was significantly reduced (Table 3).
The similar trend was observed for another community parameter, species richness, which was the highest in the gut of FMF patients in remission and in healthy volunteers but much lower during disease attacks.
Freshly voided feces from six FMF patients in remission, seven in the acute phase, six healthy Armenians and one healthy subject of non-Armenian descent were collected (Table 1).
For this, freshly voided feces were collected into sterile containers from 12 FMF patients in remission, three patients in the acute stage of FMF, six healthy Armenians, and one healthy subject of non-Armenian origin (Table 1).
In order to minimize inter-individual variations, 16S rRNA gene libraries were constructed from fecal samples of 12 FMF patients in remission, three patients in the acute stage of FMF, six healthy Armenians, and one healthy subject of non-Armenian origin.
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