However, these studies cultured unsorted tumor cells under hypoxia in a stem cell medium containing EGF and FGF2; thus, it was difficult to determine which types of cells (CSCs or non-CSCs) facilitated the expansion of CSCs.
If such investigations confirm biological differences between CSCs and non-CSCs, this would imply that novel treatment strategies need to be tested specifically for their effect on CSCs.
The equilibration in a given time could be regulated by not only formation and differentiation of CSCs into non-CSCs during symmetric and asymmetric divisions but also de-differentiation of the resulting non-CSCs back to CSCs.
These represent the average number of CSCs and non-CSCs, taken across all glands.
Does BMP signaling have different effects in CSCs and non-CSCs defined by conventional criteria?
Therefore, we hypothesize that TGF- β1 affects both CSCs and non-CSCs.
Both in CSCs and non-CSCs, this marker distribution was detectable.
Three Iranian profiles with distances between 25 and 30 taxonomic units to the closest CSCS taxa were added to the CSCS and assigned with new systematic names.
Cx43 was expressed at much lower levels in CSCs than in non-CSCs.
Bao et al. showed that CD133+ glioblastomas CSCs are more resistant to RT than non-CSCs.
The isolation and identification of CSCs could help to develop novel therapeutic strategies specifically targeting CSCs.
