Kaplan Meier estimates of DFS at 5 years were 0.51 for CMF, 0.56 for CMF → GT, 0.53 for A → CMF and 0.71 for A → CMF → GT.
The estimated OS at 5 years were 83% for A → CMF vs 79% for CMF.
At multivariate analysis, HR was 0.86 for CMF → GT, 0.86 for A → CMF and 0.53 for A → CMF → GT as compared to the reference CMF arm.
Extensive simulations are conducted to evaluate the performance of CMF, and the results demonstrate that CMF achieves the two design goals: fair bandwidth allocation and short multicast latency.
Third, classical CMF regimen was significantly inferior to non-CMF regimens for patients with luminal B and Her2/neu subtypes.
Second, classical CMF regimen was not inferior to Non-CMF regimens for patients with luminal A subtype and triple negative subtype.
All patients had metastatic axillary nodes; drug regimens were: CMF x 9 courses +/- Tamoxifen (TM) and CMF x 6 courses; median age was 43 (range 26-54).
The study scheme compared radiotherapy alone vs radiotherapy plus CMF chemotherapy, or radiotherapy plus tamoxifen or radiotherapy plus CMF plus tamoxifen (Bartelink et al, 1997).
The sequential doxorubicin → CMF (CMF=cyclophosphamide, methotrexate, fluorouracil) regimen has never been compared to CMF in a randomised trial.
If the CMF completely explained the variations in FFA response, then the CMF-corrected stimuli should have produced equal responses in FFA.
