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The patients were also evaluated with the Clinical Dementia Rating (CDR): seven had CDR of 0, nine had CDR of 0.5, and four had CDR of 1.0.
Computational analysis showed that the paratopes include the whole CDR H3, while additional CDR residues form shallow binding pockets.
In particular, two positions in CDR H2 (H58 and H59) greatly influenced antigen binding by controlling the pocket shape between CDR H2 and CDR L3 (Fig. 2).
Lt Cdr (Acting Cdr) Christopher Stephen Franks.
Wing Cdr Mark Phelps.
Lt Cdr Steven Heap.
Lt. Cdr. (Rtd).
Lt Cdr Dereck Malcolm Payne.
OBE Wing Cdr Andrew Dickens.
ARRC Lt Cdr Suzanne Lorraine Gardner-Clark.
Lt Cdr Jack Rickard, Royal Navy.
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