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BSI, 3462 (51%) BSI due to GNB, including 1345 (41%) BSI due to R isolates.
The difference between the four groups of patients without metastases (M0) and with metastases BSI < 1, BSI = 1 to 5 and BSI > 5 was statistically significant (p < 0.001).
MDR Gram-negative BSI are associated with recurrent BSI, longer hospital stays, and increased mean inpatient costs.
Primary BSI was defined as a BSI without an obvious focus or related to intravascular catheters.
BSI concordance was perfect (κ = 1.00) when only primary BSI cases, i.e. Europe-defined BSI with either "catheter" or "unknown" origin and US-defined "LCBI", were analyzed.
Of these, 64 were definitely associated with BSI, and 17 were probably associated with BSI.
In accordance with their BSI values at baseline, these patients were stratified in three BSI categories: BSI =0 (n =84), BSI ≤1 (n =30) and BSI >1 (n =32).
In accordance with their BSI values at follow-up, these patients were stratified in three BSIcategories: BSI =0 (n =55), BSI ≤1 (n =44) and BSI >1(n =47).
This adjusted effect of BSI is very close to the unadjusted effect of BSI on survival.
Catheter-related BSI and BSI of unknown origin were defined as primary BSI.
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a Pair-correlation function (Eq. 1) of nanopillar tip positions as a function of distance between pillars for bSi-1, bSi-2, and bSi-3 substrate.
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