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Herein, we focus on the comparison of in vitro osteogenic efficacy in mouse C2C12 pre-osteoblasts of three BMP members, namely: BMP-2, BMP-6 and BMP-7.
This modification makes L51P a BMP receptor-inactive inhibitor of BMP antagonists.
Tsg forms a ternary complex with Chordin and BMP, making Chordin a better BMP inhibitor.
You could be changing the amount of BMP or the number of BMP receptors.
Among these BMP subtypes, only the induction of BMP-6 expression was observed.
This effect was BMP specific and could be blocked by BMP antagonists.
Similar(11)
Nevertheless, type I and type II receptor utilization differs significantly between BMP-2/BMP-4 and BMP-6/BMP-7.
Stimulation of cells with BMP-4 activates the canonical and non-canonical BMP pathways.
The engineered BMP-2 showed reversible binding to Ti surfaces and induced BMP signaling activity.
These results correlate with FN/BMP affinity for TiHA, since BMP-6 > BMP-2 > BMP-7.
In vitro assays demonstrated cross-reactivity of chimeric anti-BMP-2 mAb with BMP-4 and BMP-7.
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