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CD19 is the activating co-receptor of BCR, which promotes BCR signaling when co-localizing with BCR in the lipid raft during B cell activation.
Interestingly, the first order derivatives that capture longitudinal changes in PSADT clearly distinguished between the BCR and non-BCR, suggesting that longitudinal follow-up of PSADT could provide an accurate predictor of BCR (Fig. 2c).
Their cost-effectiveness is measured in terms of the benefit-to-cost ratio (BCR) and the probability that BCR exceeds unity – i.e., Pr BCR > 1).
Note: The underlined BCR value 2.48 indicates the BCR for base case.
In general, 3 breakpoint cluster regions in the BCR gene have been described: major (M-bcr), minor (m-bcr), and micro (μ-bcr).
Breast Cancer Research : BCR 11(4): R44.
Cav1 and the BCR are in close proximity after BCR stimulation.
Capasso, M. et al. HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species.
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Full-length c-BCR as well as BCR sequences retained in BCR-ABL bind specifically to the SH2 domain of ABL.
These data identify EGR1 as a signaling intermediate in BCR-stimulated B cell functional responses, specifically linking BCR signal transduction to induction of the Icam-1 gene.
All M-bcr coordinates are relative to chr22 23,522,552 (start position of BCR gene).
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