Sentence examples for * abrogation in from inspiring English sources
Chapter I (The role of PDGF signalling in (patho)- physiologic lung development) emphasizes the importance of PDGF-Rα expressing myofibroblasts (MFBs) in alveolarization that is hindered by mechanical ventilation and stretch causing abrogation in the receptor leading to reduced migration and disrupted elastin deposition.
This result suggests that the lethality from the deletion of Cdk2ap1 is not due to the abrogation in the hatching process.
These results suggested that E6/E7 indeed contribute to the metastatic process and raise a rational for its abrogation in cervix cancer patients by using an anti-viral agent, Cidofovir, as a therapeutic tool.
Indeed, pRb abrogation in several epithelial cell lines has been shown to induce changes associated with an EMT, including such a cadherin switch in which cadherin1/E-cadherin/CDH1 is replaced by N-cadherin [45]-[47] [45]-[47]
Interestingly, β-catenin abrogation in the mesenchyme specifically interferes with the amplification of the PSMC progenitors but does not affect, at least in vitro, their differentiation into smooth muscle cells.
We termed this event the vascular component of the tumor (or tissue) response, and showed that its abrogation in acid sphingomyelinase (ASMase -, Bak-, or Bax-deficient mice resulted in resistance to single dose radiotherapy.
Indeed, in our experimental system, Trf1 abrogation results in a dramatic reduction in the number and the size of malignant lung carcinoma lesions, even in the absence of p53, already in the first mouse generation and in the absence of telomere shortening, indicating that Trf1 deficiency severely impairs cancer progression in the context of oncogenic K-Ras.
CD22ΔE12-depletion in transfected ALL-1 was associated with abrogation of in vitro proliferation and clonogenicity, as reflected by a drastic decrease in the number and cellular content of colonies formed in semi-solid methylcellulose cultures (Fig. 6B).
The large quantity of DNA damage sustained by these cells due to checkpoint abrogation results in mitotic catastrophe and subsequent cellular death from this mitosis.
Moreover, complete APN abrogation results in only mild phenotypic change, unless pathologically challenged (e.g., by high-fat diet or ischemia), suggesting existent overlapping regulators.
This abrogation would in turn decrease phosphorylation of the associated catenins, thus leading to upregulation of the cell adhesion molecule E-cadherin, which may ultimately result in inhibition of prostatic tumour progression.
