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Cytoplasmic AAT and mitochondrial AAT function in tandem with malate dehydrogenase to cycle the malate-aspartate shuttle.
Small periodic acid-Schiff diastase positive intrahepatic granules and positive staining with antibodies against AAT protein suggested an AAT deficiency.
While only 13 cases (13%) were negative for AAT expression, 89 cases (87%) contained AAT at varying degrees.
AAT is quantified by immunologic measurement of AAT in serum, the phenotype characterized by isoelectric focusing, the common genotypes by targeted DNA analysis, and by sequencing the coding region of the gene when the AAT abnormality remains undefined.
The evolution of the aspartate transaminases, also called aspartate amino transferases (AAT) family, revealed five major duplications separating bacterial AAT (TyrB and AspC) from mitochondrial AAT (AATM or GOT2) and cytoplasmic eukaryote AAT families (AATC or GOT1).
Here we demonstrate how polymorphisms in the AAT gene can lead to genotype/phenotype discrepancies in common AAT assays.
P-value A*: from the comparison of mean values of serum AAT in the control and CRC groups, and between the mean AAT in the control group and the partial AAT value for each TNM subgroup.
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The prognostic significance of AAT expression in lung adenocarcinomas has been evaluated using immunohistochemistry [ 47]; strongly AAT-positive cases had a worse prognosis than weak-to-moderately AAT-positive or AAT-negative cases, suggesting that increased AAT expression in lung adenocarcinoma patients may be a prognostic indicator.
Intervention: Daily AAT with (n = 20) or without (n = 20) knowledge of results, or no AAT (n = 20) during a 3-week intervention period.
AAT activity, in the presence of several concentrations of oxamate was measured to determine in vitro AAT inhibition.
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